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Molecular Imaging Chemistry Laboratory (MICL)

 

Research

Read more at: Imaging Neurodegeneration

Imaging Neurodegeneration

Imaging Neurodegeneration Target: a-synuclein, tau protein, amyloid-b, OPC PET radiotracer candidates: EMF26, LM229, OT049 Alzheimer’s, Parkinson’s, Huntington’s Disease, dementia with Lewy Bodies, and multiple sclerosis are characterised by the progressive loss of neurons and are classed as...

Read more at: Imaging CNS Receptors

Imaging CNS Receptors

Imaging CNS Receptors Target: TSPO, PDE1 PET radiotracer candidate: GE387, SK42 In addition to aggregate pathology, many neurodegenerative diseases are characterized by the presence of activated microglia which are indicators of neuroinflammation. TSPO is probably the most studied neuroinflammation...

Read more at: Imaging Protein Synthesis

Imaging Protein Synthesis

Imaging Protein Synthesis Target: rate of protein synthesis PET radiotracer candidates: [ 11 C]PURO and [ 18 F]FEPURO Besides two main research themes of neurodegeneration and CNS receptor imaging, we are also interested in other hallmarks of disease, such as rate of protein synthesis. Imaging...

Read more at: Radiochemical Methodology

Radiochemical Methodology

Radiochemical Methodology New methods for radiosynthesis of known PET radiotracers In our lab we are also interested in applying new methodologies to synthesis of radiotracers. Serotonin transporter (SERT) regulates concentration of synaptic serotonin and for this reason is involved with various...

Read more at: New In Vitro Methods

New In Vitro Methods

New In Vitro Methods Binding assays and biophysical methods One of the important stages in the PET radiotracer development is the in vitro evaluation of candidates with the aim of establishing a lead compound. For this, in our group we use known methods (e.g., receptor binding affinity assay) to...

Read more at: Publications

Publications

Fisher, M. J.; McMurray, L.; Lu, S.; Morse, C. L.; Liow, J.-S.; Zoghbi, S. S.; Kowalski, A.; Tye, G. L.; Innis, R. B.; Aigbirhio, F. I.; Pike, V. W. Front Cover: [Carboxyl-11C]Labelling of Four High-Affinity cPLA2α Inhibitors and Their Evaluation as Radioligands in Mice by Positron Emission...

Read more at: EPSRC Project

EPSRC Project

EPSRC Project A common feature of all dementias e.g. Alzheimer's, Parkinson's and Huntington's diseases are the presence of specific proteins in the brain, which due to having abnormal structures, accumulate into increasingly large assemblies and fibrils. These structures, which are present in many...

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