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Molecular Imaging Chemistry Laboratory (MICL)


Simon’s article is entitledThe Inverse Electron Demand Diels Alder Cycloaddition with Carbon-11 and Fluorine-18 – A Gateway to Pretargeted Imaging across the Blood-Brain Barrier”. This article is part of a special issue of the journal titled “Blood Brain Barrier - tactics and attributes in developing successful neuroimaging agents”.  Simon’s review article highlights advancements in the development of trans-cyclooctenes (TCOs) and tetrazines which have been radiolabelled with either carbon-11 or fluorine-18 for use in pre-targeted PET imaging across the blood–brain barrier (BBB).

Currently there is increased focus on developing tools to image large biomolecules such as antibodies within the brain using positron emission tomography (PET) and this review is a timely overview of the current state of the field.