Submitted by Virginia Wykes on Wed, 31/05/2023 - 15:09
Just after starting her PhD at MICL, Catherine Dickmann had her MSc research report published in Chemical Communications, titled: Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. In summary:
Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been targeted for molecular imaging of cancer. Catherine and colleagues report the development of a novel molecule radiolabelled with positron emitting fluorine-18, [18F]BiPET-2, and its in vitro and preclinical evaluation in glioblastoma models.